Karen Elaine Magee Pape
Revised January 2016

McGill University, BSc
University of Toronto, MD
Hospital for Sick Children, University of Toronto, FRCPC, Pediatrics
Duncan L. Gordon Research Fellow, The Hospital for Sick Children Foundation

  • Year 1 – Hammersmith Hospital, London, England, Neonatal Pathology – Supervisor Dr. Jonathan S. Wigglesworth
  • Year 2 – University College Hospital, London, England, Neonatal Unit – Supervisor Dr. Osmond Reynolds

Fellow of the Royal College of Physicians and Surgeons of Canada – Emeritus
Fellow of the American Academy of Pediatrics – Emeritus

American Academy for Cerebral Palsy and Developmental Medicine
International Society for Restorative Neurology
Canadian Pediatric Society

Past Appointments
The Hospital for Sick Children, Toronto 1979-1989

  • Neonatologist
  • Director of Neonatal Follow-up Program
  • President of the Medical Staff (1984-1986)

University of Toronto 1979-1996

  • Associate Professor, Pediatrics, Institute of Biomedical Engineering, Department of Community Health, Division of Exercise Sciences
  • Associate Member, School of Graduate Studies

Medical Director, the Magee Clinic, Toronto 1989-1996
Medical Director, TASC Network Inc. 1996 – 2010

Current Positions
Editorial Board – Journal of Brachial Plexus and Peripheral Nerve Injury
Medical Advisory Boards:
Reaching For The Stars: A Foundation of Hope for Cerebral Palsy
The Weinberg Family Cerebral Palsy Center, Columbia University
The Preemie Study Portal
Children’s Cerebral Palsy Movement

SENTAC – 2016 Robert Ruben Award for Scientific Achievement
2016 Pathways Pioneer Award
Euro-Peds Foundation – 2017 Pacesetter Award


1. Magee, K., BaSinka, J., Quarrington, B., and Stancer, H.C.: Blindness and menarch. Life Sci. 9:9-12, 1970.
2. Pape, K.E. and Pickering, D.: Asymmetric crying facies: An index of other congenital anomalies. J. Pediatr. 81:21-30, 1972.
3. Fitzhardinge, P.M., Pape, K.E., Arstikaitis, M., Boyle, M., Ashby, S., Rowley, A., Netley, C., and Swyer, P.R.: Mechanical ventilation of infants of less than 1501 grams birth weight: Health, growth and neurologic sequelae. J. Pediatr. 88:631-641, 1976.
4. Pape, K.E., Armstrong, D.L., and Fitzhardinge, P.M.: Central nervous system pathology associated with mask ventilation in the very low birthweight infant: A new etiology for intracerebellar hemorrhages. Pediatrics 58:473-483, 1976.
5. Pape, K.E., Buncic, R., Ashby, S., and Fitzhardinge, P.M.: The status at two years of low-birthweight infants born in 1974 with birthweights of less than 1,001 grams. J. Pediatr. 92:253-260, 1978.
6. Pape, K.E., Armstrong D.L., and Fitzhardinge, P.M.: Peripheral median nerve damage secondary to brachial arterial blood gas sampling. J. Pediatr. 93:852-856, 1978.
7. Wigglesworth, J.S., and Pape, K.E.,: An integrated model for haemorrhagic and ischaemic lesions in the newborn brain. J. Early Hum. Develop. 2:179-199, 1978.
8. Pape, K.E., Blackwell, R.J., Cusick, G., Sherwood, A., Houang, M.J.M., Thornburn, R.J., and Reynolds, E.O.R.: Ultrasound detection of brain damage in preterm infants. Lancet 313:1261-1264, 1979.
9. Lipscombe, A.P., Blackwell, R.J., Reynolds, E.O.R., Thornburn, R.J., Cusick, G., and Pape, K.E.: Ultrasound scanning of brain through the anterior fontanelle of newborn infants. Lancet 314:39, 1979.
10. Wigglesworth, J.S., and Pape, K.E.: Pathophysiology of intracranial haemorrhage in the newborn. J. Perinat. Med. 8:119-133, 1980.
11. Thornburn, R.J., Lipscombe, A.P., Stewart, A.L., Reynolds, E.O.R., Hope, P.L., and Pape, K.E.: Prediction of death and major handicap in very preterm infants by brain ultrasound. Lancet 1:1119-1121, 1981.
12. Pape, K.E., Bennett Britton, S., Szymonowicz, W., Martin, D.J., Fitz, C.R., and Becker, L.: Diagnostic accuracy of neonatal brain imaging: A post-mortem correlation of computed tomography and ultrasound scans. J. Pediatr. 102:275-280, 1983.
13. Nwaesei, C.G., Pape, K.E., Martin, D.J., Becker, L.E., Fitz, C.R.: Periventricular leukomalacia (PVL) diagnosed by ultrasound: A post-mortem correlation. J. Pediatr. 105:106-110, 1984.
14. Martin, D.J., Pape, K.E., Daneman, A.: The site of neonatal periventricular hemorrhage, An important prognostic sign of mortality and morbidity. Annales de Radiologie. 27:243-246, 1984.
15. Zarfin, J., Pape, K.E., Nwaesei, C., Martin, D., Daneman, A., and Murphy, W.: Hemorrhagic and Ischemic Lesions in the Preterm Brain. Pediatric Research. 18;381A, 1984
16. Butt, W., Havill, D., Daneman, A., Pape, K.E.: Hemorrhage and cyst development in the cavum septi pellucidi and cavum vergae. Pediatr. Rad. 15:368-371, 1985.
17. Rivlin, J., Pape, K.E., Reilly B., Smallhorn, J., Levinson, H.L. Long term follow-up of children with the Mikity-Wilson syndrome. Euro. J. Resp. Dis. 67:286-293, 1985.
18. Koren, G., Butt, W., Chuang, H., Pape, K.E.: Neonatal seizures associated with morphine sulfate. Vet. Hum. Toxicol. 27:519-520, 1985.
19. Koren, G., Butt, W., Chinyanga, H., Soldin S., Tan, Y-K., Pape, K.E.: Postoperative morphine infusion in newborn infants: Assessment of disposition characterisitcs and safety. J. Pediatr. 197:963-970, 1985.
20. Koren, G., Butt, W., Maher, J., Pape, K.E., MacLeod, S.: Intravenous paraldehyde for seizure control in newborn infants. Neurology 36:108-111, 1986.
21. Zarfin, J., Van Aerde, J., Perlman, M., Pape, K.E., Chipman, M.L.: Predicting survival of infants of birth weight less than 801 grams. Crit. Care Med. 14:768-772, 1986.
22. Gillian, J.E., Pape, K.E., Cutz, E.: Association of changes in bombesin immunoreactive neuroendocrine cells in lungs of newborn infants with persistent fetal circulation and brainstem damage due to birth asphyxia. Pediatr. Res. 20:828-833, 1986.
23. Boulton, J.E., Ein, S.H., Reilly, B.J., Smith, B.T., and Pape, K.E.: Necrotozing entercolitis and volvulus in the premature neonate. J. Pediatr. Surg. 24:901-905, 1989.
24. White A.M., and Pape, K.E.: The Slump Test – An assessment tool for evaluating sitting position. Amer. J. Occ. Ther. 46:271-274, 1992.
25. Pape, K.E., Galil, A., Boulton, J.E., Kirsch, S.E., White, A.M., and Chipman, M.: A neuromuscular approach to the motor deficits of cerebral palsy: A pilot study. J. Ped. Orthop. 13:628-633, 1993.
26. Kirsch, S.E., Watson, S., Gilmour, R.F., Shandling, B., and Pape, K.E.: Continence following electrical stimulation and EMG biofeedback in a teenager with imperforate anus. J. Ped. Surg. 28:1408-1410, 1993.
27. Pape, K.E.: Caution urged for NMES use. Phys Ther. 74:265-267, 1997
28. Boulton, J.E., Kirsch, S.E., Chipman, M., Etele, E., White, A.M., and Pape, K.E.: Reliability of the Peabody Developmental Gross Motor Scale in children with cerebral palsy. Physical & Occupational Therapy in Pediatrics 15:35-51, 1995.
29. Pape, K.E.: Therapeutic Electrical Stimulation (TES) for the Treatment of Disuse Muscle Atrophy in Cerebral Palsy. Pediatric Physical Therapy 9(3):110-112, 1996
30. Gross, R.H., Scottow, C., and Pape, K.E.: Therapeutic Electrical Stimulation for the Treatment of Muscle Weakness Associated with Clubfoot. J Pediatr Orthop B 6(4):289, 1997
31. Scarfone, H., McComas, A.J., Pape, K.E., and Newberry, R.: Denervation and reinnervation in congenital brachial plexus. Muscle & Nerve 22:600-607, 1999.
32. Brown, T., Cupido, C., Scarfone, H., Pape, K.E., Galea, V., and McComas, A.J.: Developmental apraxia arising from neonatal brachial plexus palsy. Neurology 55:24-30, 2000.
33. Pape, K.E.,: Developmental and maladaptive plasticity in neonatal SCI. Clin Neurol Neurosurg 114(5):475-82, 2012


1. Fitzhardinge, P.M., Pape, K.E., and Armstrong, D.L.: Intracerebellar hemorrhage following mask ventilation. In Intensive Care in the Newborn, L. Stern, ed. Masson Publications, New York, 1976.
2. Fitzhardinge, P.M., Kalman, E., Ashby, S., and Pape, K.E.: Present status of the very low birthweight infant treated in a referral Neonatal Intensive Care Unit in 1974. In The Cost of Preventing Major Mental Handicap, CIBA Found. Symp. 59. Elsevier/Excerpta Medical/North-Holland, Amsterdam, 1978.
3. Pape, K.E., and Wigglesworth, J.S.: Haemorrhage, Ischemia, and The Perinatal Brain. Clinics in Developmental Medicine, Spastics International Medical Publications. William Heinemann Medical Books Limited, London, and J.B. Lippincott Company, Philadelphia, 1979.
4. Fitzhardinge, P.M., and Pape, K.E.: Follow-up studies of the high risk newborn. In Neonatology: Pathophysiology and Management of the Newborn, 2nd Edition, G.B. Avery, ed., J.B. Lippincott Co., Philadelphia, 1981.
5. Pape, K.E., and Fitzhardinge, P.M.: Perinatal damage to the developing brain. In Advances in Perinatal Medicine, Vol. I. A. Milunsky, E. Friedman, and L. Gluck, eds. Plenum Medical Book Col., New York, 1981.
6. Pape, K.E.: Intraventricular hemorrhage: Diagnosis and outcome. In The Fetus and Newborn, Vol. XVII, No. 1, A.D. Bloom and L.S. James eds. Alan R. Liss, Inc., New York, 1981.
7. Pape, K.E.: Perinatal brain damage. In Respiratory Distress Syndrome. K.O. Raivio, N. Hallman, K. Kouvalainen, I. Valimaki, eds. Academic Press Inc., London, 1983.
8. Pape, K.E., and Galil, A.: Follow-up of the high risk infant: Methodological problems. In Perinatal Brain Lesions, K.E. Pape and J.S. Wigglesworth, eds. Blackwell Scientific Publications Inc., Boston, 1989.
9. Pape, K.E., and Wigglesworth, J.S., eds. Perinatal Brain Lesions. Contemporary Issues in Fetal and Neonatal Medicine Series, Vol. 5, Blackwell Scientific Publications Inc., Boston, 1989.
10. Pape, K.E.: Etiology and pathogenesis of intraventricular hemorrhage in newborns (Commentary). Pediatrics 84:382-385, 1989.
11. Pape, K.E., Kirsch, S., and Bugaresti, J.: New therapies in spastic cerebral palsy. Contemporary Pediatrics 1:6 -13 1990.
12. Pape, K.E., and Kirsch, S.E.: Technology-assisted self-care in the treatment of spastic diplegia. In the Diplegic Child, M.D. Sussman, ed. American Academy of Orthopedic Surgeons, Rosemount, IL. 1992.
13. Pape, K.E., and Chipman, M.L.: Electrotherapy in rehabilitation. Physical Medicine and Rehabilitation: Principles and Practice, J.A. Delisa, B.M. Gans, N.E. Walsh, et al eds. Lippincott, Williams & Wilkins, Baltimore, MD. 2004.
14. Pape, K.E.: The Boy Who Could Run But Not Walk: Understanding Neuroplasticity in the Child’s Brain. Barlow Books, Toronto, 2016.